Bypass Surgery Might Be History Soon.....

Bypass Surgery Might Be History Soon.....

In a ground breaking discovery that may eventually render bypass surgery history, researchers at Tel Aviv University have shown that an injected protein can regrow blood vessels in the human heart.

In heart disease, blood vessels are either clogged or die off, starving the heart of oxygen and leaving it highly susceptible to a cardiac attack.

Dr. Britta Hardy of TAU's Sackler School of Medicine and her team of researchers have developed a protein-based injection that when delivered straight to muscles in the body, sparks the regrowth of tiny blood vessels.

The new vessels in the heart could give millions of people around the world a new lease on life.

"The biotechnology behind our human-based protein therapy is very complicated, but the goal is simple and the solution is straightforward. We intend to inject our drug locally to heal any oxygen-starved tissue.

So far in animal models, we've seen no side effects and no inflammation following our injection of the drug into the legs. The growth of new blood vessels happens within a few weeks, showing improved blood circulation," said Hardy.

The protein solution can also be added as a coating to a stent. Usually, the implantation of a stent is accompanied by a high risk for blood clots, which necessitates the use of blood thinners.

"We could coat a stent with our peptide, attracting endothelial stem cells to form a film on the surface of the stent. These endothelial cells on the stent would eliminate the need for taking the blood thinners that prevent blood clots from forming," said Hardy.

If investment goals are met, the researchers are hoping that toxicity studies and Phase I trials could be complete within two years.

The researchers began the study for preventing leg amputations, positing that proteins from the human body could be used to trigger the growth of new blood vessels.

Hardy started by studying a library of peptides and testing them in the laboratory and later confirmed initial results. She then took some of the isolated and synthesized peptides and tested them in diabetic mice whose legs were in the process of dying.

Although diabetes is known to decrease blood circulation, Hardy found that her therapy reversed the decrease. "Within a short time we saw the formation of capillaries and tiny blood vessels.

After three weeks, they had grown and merged together with the rest of the circulatory system," she said. In mice with limited blood circulation, she was able to completely restore blood vessels and save their legs.

It was then a short step to studying the applicability of the research to cardiac patients. "It''s pretty obvious if there is regrowth or not.

Our technology promises to regrow blood vessels like a net, and a heart that grows more blood vessels becomes stronger. It's now imaginable that, in the distant future, peptide injections may be able to replace bypass surgeries," concluded Hardy.

The study has been published in Biochemical Pharmacology more  

View all 9 comments Below 9 comments
V.good information, thanks. more  
It is humble attitude of knowledgeable man Mr. Raja Chandra. more  
a heartening news and thanks to the informer. more  
great piece of information...tks raja sahib more  
Post a Comment

Related Posts

    • Secrets of Longevity

      Whales have heart rates @2/minute while in water and it's up by 4 while out of water,while hunting. Humans have heart rates between 60-80 and athletic people or others who believe in reg...

      By Dr. Neelam Nath
      /
    • Healthy cholesterol

      Can we run our vehicle without good oil? Why do we get our vehicles serviced, get filter & oil changed after driving few thousands of Kilometers? Cholesterol is a type of fat found i...

      By Neelam Nath
      /
    • Alkaline diet

      If you are in your 30s or know someone who is in their 30s, then it is important to understand that alkaline diet hams none and helps everyone without being a burden on the pocket. Dr Otto Warburg,...

      By Neelam Nath
      /
    • Foods as blood thinners

      Foods As Blood Thinners Dr. Neelam Nath Bhatia Dr. Neelam Nath BhatiaGeneral Physician 9 September, 2019 Cardiac patients are given blood thinners so that bloo...

      By Neelam Nath
      /
    • Chelation therapy

      is Chelation therapy advisable for reducing blocks

      By Swarnalatha Marjee
      /
    • BP fluctuation during day

      How does blood pressure fluctuate during the day? Is it quite high before lunch. Experts please advise.

      By Sneha Goyal
      /
    • Erroneously high BP measurement mistakes

      AHA lists 7 common mistakes leading to erroneously high BP measurement . 1 .Having a full bladder can add 10-15 points to your reading. 2 .Slouching, unsupported back or feet....

      By Sneha Goyal
      /
    • Hypertension

      Hypertension is a systolic blood pressure equal to or greater than 140mm of Hg or diastolic pressure equal to or greater then 90 mm of hg. Features of Hypertension: 1. Headach...

      By Pritam Sharma
      /
    • 101 year old cardiologist

      India's first lady Cardiologist, Dr. Padmawati Sivaramakrishna Iyer turned 101yrs on 20th June 2018. She is director of the National Heart Institute, Delhi and the founder president of the A...

      By Sneha Goyal
      /
    • Good evening friends

      4 Nuts That Cut Your Heart Disease Risk. Recently, I set up an experiment in a grocery store. I placed four nut mixes on a shelf. Each was labeled differently. One promoted men’s h...

      By Dr.(Mrs.)Chandra Kanta Gosain
      /
    • KNOW YOUR HEART

      25 Facts About THE Heart that WILL Leave you Stunned. Here are 25 facts you may not have known about your incredible heart ~ Every day you are alive, your heart creates enough...

      By Dr.(Mrs.)Chandra Kanta Gosain
      /
Share
Enter your email & mobile number and we will send you the instructions

Note - The email can sometime gets delivered to the spam folder, so the instruction will be send to your mobile as well

Please select a Circle that you want people to invite to.
Invite to
(Maximum 500 email ids allowed.)