Why 4th wave may be a little far away

Will BA.2.12.1 be the next catalyst for infections worldwide?

This sublineage has one specific mutation in the RBD: a substitution of lysine for glutamine at position 452 (L452Q).

This is notable for two reasons. First, L452Q has been previously identified in several variants of concern, like Lambda, Delta, Delta plus, and Epsilon

Second, unlike many mutations where we must only speculate on their impact on viral fitness, L452Q was studied and found to increase escape immunity, allowing the virus to attach more strongly to human cells and avoid neutralizing antibodies

The second mutation is more mysterious. It is a substitution from serine to leucine at position 704 (S704L). Unlike L452Q, S704L is a relatively rare mutation by way of major variants, and its exact impact on the virus is unstudied

Based on its position in the S2 region of the Spike protein, we can speculate that the mutation may affect either viral fusion or furin cleavage efficiency, but further study would be welcome

We can say with near certainty that BA.2.12.1 is at least as transmissible and immune evasive as BA.2. It is unlikely that the two Spike mutations would decrease either of these facets of the virus strain

However, due to the wealth of BA.2 cases in previous months, the BA.2.12.1 virus may be impeded by antibodies developed from infections during that wave, which could explain why cases are low relative to the Omicron wave

It is critical to remain vigilant in our surveillance of these subvariants. Recent reports from Hong Kong note that Omicron BA.2 subvariants deliver a similar fatality risk to those infected relative to earlier strains of SARS2

This is contrary to many assumptions that Omicron is less severe than previous strains. Additionally, there are indications that Omicron is as dangerous in terms of long-term complications in children as the Delta variant of last summer

A new wave of Omicron with BA.2.12.1 or another variant yet to be identified could be as catastrophic as the wave caused by earlier VOCs including Delta

So, which sub-variant is the fittest? BA.2.12.1, BA.4 or BA.5? While the latter two are surging in SouthAfrica & Europe, the former is making strongholds in the US. Let’s wait & see, but be vigilant!! more  

Insightful post more  
The Corona pandemic virus is lab made and therefore even the makers (China) of this virus are not being able to get a grip on it... Shanghai being the latest example. But the world is trying to pass it off as just another kind of flu. No lockdowns. Keep the world open and working. For the sake of repercussions on world economy. We fully understand and agree with this attitude as long as governments can strictly enforce basic Covid protocols. This is necessary to keep the health situation as well as economic situation under control globally. However my concern is mainly for the little kids who are the only vulnerable part of the global population because they cannot be expected to diligently follow Covid protocols to protect themselves. Therefore I request the members of this prestigious Circle forum to help in bringing about awareness for authorities to start Online Classes only for these little ones from Montessori Nursery Kindergarten... upto Class 1 and 2 atleast. We must save the children from long Covid health problems and from getting sick all the time that they are being mandatorily forced to attend physical school. attend physical school. more  
Right from the original Alpha "variant", every Covid wave has been "deadly" only due to constant media fear mongering more  
Covid virus is not natural ,vaccine is not natural so response is also irrational . more  
https://www.forbes.com/sites/williamhaseltine/2022/04/22/survival-of-the-fittest-the-rise-of-ba2121/ more  
Post a Comment

Related Posts

    • Junk consumption soaring only bad to follow

      Varun Beverages sold 480 Cr Litres of Pepsi and other Beverages in FY23 Dominos India sold 6.7 cr to 7.83 cr Pizzas in FY23 Pizza hut India (Sapphire) sold abou...

      By Sudesh Rai
    • Are we going to have a rabies and dog bit epidemic

      LocalCircles Manager and members are doing excellent work in sensitising the Government to take dog bite menace seriously and on the other hand we have officers like District Magistrate Noida who a...

      By Radha Puri
    • Banking difficulties of people

      Thrilled to see LocalCircles banking difficulties survey in multiple english hindi news papers yesterday.

      By Shailesh Deshmukh
    • Appeasing minorities by giving vehicle subsidies

      Is a really wrong policy that is being deployed bh Karnataka Government. The only way such subsidies must be given is based on economic status (basis tax returns) and not caste. We all r...

      By SN Mittal
    • Kudos LocalCircles

      Great work on bank malpractices and escalating this issue to RBI. All members who have a loan need to save the attached notification in their mobile/computer. Your bank will now have to...

      By Shikha Jain
    • Need safety standards for commercial public events

      A lot of women who went to the AR Rahman concert this weekend had to face horror. Many, i mean a lot were groped and assaulted.

      By Sarita S
    • High costs of medical education

      It is costing anywhere between 1.5 crores to 4 crores for a medical specialisation MD degree. How many people in middle class have this kind of money in their banks which means only chi...

      By Sarita Ravichandran
    • G-20 India - Declarations

      Attached for all those who are interested. This circle has such knowledgeable people. We should discuss how these broad areas of consensus can be translated into real areas of actions on the ground

      By Ashima Gupta
    • Medicine Side Effects information to consumer

      Both the news papers I receive here in Noida have the localcircles survey published on the unknown side effects of medicines

      By RN Chopra
    • Fantastic survey by LocalCircles on airline seat charges

      Yesterday someone in my mom’s school group shared the LocalCircles survey in charges for seats in flights.

      By Radha Puri
    • 10 years gone by

      In May 2014 the price of petrol was ₹ 71.41 and now it is ₹101.94 Price of diesel was ₹ 55.49 per litre in May 2014 and now it is ₹ 87.98 per litre Crude O...

      By Ruchika L Maheshwari
Enter your email and mobile number and we will send you the instructions

Note - The email can sometime gets delivered to the spam folder, so the instruction will be send to your mobile as well

All My Circles
Invite to
(Maximum 500 email ids allowed.)