E484K coronavirus variant neutralising antibodies
You know how the world put travel bans against UK travel out of fear of the B117 more contagious variant? Well, now, UK put travel ban from Latin America & Portugal because U.K. thinks Brazil COVID19 variant is worse.
At least two coronavirus variants are currently circulating in Brazil, and at least one has slipped its borders, traveling to Japan. Japanese authorities found one of those variants in four people traveling from Brazil earlier this week...
The variant contains a mutation that has been linked with higher contagiousness, similar to the variant found in UK and another in South Africa. Like the variant found in South Africa, the one exported from Brazil to Japan also carries a mutation that may weaken the efficacy of vaccines
This same mutation has also been identified in the other coronavirus variant recently discovered in Brazil. Experts have cautioned, however, that it would be very difficult for new variants of the coronavirus to evade vaccines entirely.
The Brazil variant Has been renamed to B1128– more specifically B.1.1.28(K417N/E484K/N501Y). There is another one called B.1.1.28(E484K)—both have the problematic E484K mutation that can escape antibodies!
Why are we so worried about this one? Because like the South Africa B1351 variant, the new ones also have the E484K mutation. In a recent study, E484 mutation (inside the SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies—bad.
Well, How much escape? the E484K shows a 10x reduction of neutralization (“neutralization” = stopping the virus)
by various antibodies compared to wildtype (common SARSCoV2) in some patients —a rather bad thing. It means the virus with E484K is worrying for “immune escape”. more